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Anna zhang
China, Hebei, shijiazhuang, 050000
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Thursday, September 8, 2022 at 11:13:26 AM Pakistan Standard Time


Etomidate Structure

Etomidate structure

Common Name Etomidate
CAS Number 33125-97-2 Molecular Weight 244.289
Density 1.1±0.1 g/cm3 Boiling Point 391.5±17.0 °C at 760 mmHg
Molecular Formula C14H16N2O2 Melting Point 72-74ºC
MSDS Chinese USA Flash Point 190.6±20.9 °C
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning

 Use of Etomidate

Etomidate(R-16659) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.Target: GABA ReceptorEtomidate is a potent inhibitor of the adrenal response to surgery. The absence of clinical consequences associated with the blunted response suggests that a major increase in adrenal hormone production may not be necessary during surgery [1]. Etomidate is an intravenous induction agent that is associated with hemodynamic stability during intubation. The agent is therefore attractive for use in critically ill patients who have a high risk of hemodynamic instability during this procedure [2]. Etomidate use was not associated with all cause 28-day mortality or hospital mortality but was associated with significantly higher ICU mortality (91% vs. 64% for etomidate and controls groups, respectively; p = 0.02). Etomidate patients who received subsequent doses of hydrocortisone required lower doses of vasopressors and had more vasopressor-free days but no improvement in mortality [3].Clinical indications: FDA Approved Date: 1983Toxicity: Undesirable side effects of etomidate that may limit its use include pain on injection, myoclonus and adrenocortical suppression lasting 4-6 hours following an induction dose.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 391.5±17.0 °C at 760 mmHg
Melting Point 72-74ºC
Molecular Formula C14H16N2O2
Molecular Weight 244.289
Flash Point 190.6±20.9 °C
Exact Mass 244.121185
PSA 44.12000
LogP 3.26
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.562
Storage condition 2-8°C
Water Solubility DMSO: >10 mg/mL


Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.


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