|CAS Number||33125-97-2||Molecular Weight||244.289|
|Density||1.1±0.1 g/cm3||Boiling Point||391.5±17.0 °C at 760 mmHg|
|Molecular Formula||C14H16N2O2||Melting Point||72-74ºC|
|MSDS||Chinese USA||Flash Point||190.6±20.9 °C|
Use of Etomidate
Etomidate(R-16659) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.Target: GABA ReceptorEtomidate is a potent inhibitor of the adrenal response to surgery. The absence of clinical consequences associated with the blunted response suggests that a major increase in adrenal hormone production may not be necessary during surgery . Etomidate is an intravenous induction agent that is associated with hemodynamic stability during intubation. The agent is therefore attractive for use in critically ill patients who have a high risk of hemodynamic instability during this procedure . Etomidate use was not associated with all cause 28-day mortality or hospital mortality but was associated with significantly higher ICU mortality (91% vs. 64% for etomidate and controls groups, respectively; p = 0.02). Etomidate patients who received subsequent doses of hydrocortisone required lower doses of vasopressors and had more vasopressor-free days but no improvement in mortality .Clinical indications: FDA Approved Date: 1983Toxicity: Undesirable side effects of etomidate that may limit its use include pain on injection, myoclonus and adrenocortical suppression lasting 4-6 hours following an induction dose.
Chemical & Physical Properties
|Boiling Point||391.5±17.0 °C at 760 mmHg|
|Flash Point||190.6±20.9 °C|
|Vapour Pressure||0.0±0.9 mmHg at 25°C|
|Index of Refraction||1.562|
|Water Solubility||DMSO: >10 mg/mL|
Handling and Storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.